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Article
September 1974

Lymphoid Interstitial Pneumonia and Autoerythrocyte Sensitization Syndrome: A Case With Deposition of Immunoglobulins on the Alveolar Basement Membrane

Author Affiliations

From the Department of Medicine, State University of New York at Buffalo. Dr. DeCoteau was a fellow of the Canadian Arthritis and Rheumatism Society. He is now with the Department of Medicine, University Hospital, Saskatoon, Saskatchewan, Canada. Dr. Tomasi is now with the Department of Immunology, Mayo Medical School, Rochester, Minn.

Arch Intern Med. 1974;134(3):519-522. doi:10.1001/archinte.1974.00320210129019
Abstract

We have recently studied a patient with chronic pulmonary disease whose lung biopsy showed the typical histopathologic features of lymphoid interstitial pneumonia (LIP).1 Of special interest was the finding on immunofluorescence of immunoglobulin deposits in a predominantly linear pattern along the alveolar basement membrane. In addition, there was a long history of recurrent, transient bouts of hematuria plus a more recent history of ecchymotic skin lesions, which suggested the autoerythrocyte sensitization syndrome.

Patient Summary  A 17-year-old white girl was admitted to the Buffalo General Hospital in April 1968 for a diagnostic lung biopsy. There was a history beginning in infancy of numerous upper respiratory tract infections. She had experienced one episode of pneumonia. Two years prior to admission she developed an episodic cough sometimes productive of purulent sputum that was occasionally blood streaked. She was slightly short of breath after climbing one flight of stairs. The patient was

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