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Article
November 1974

Idiopathic Hypoparathyroidism With Primary Ovarian Failure: Report of a Case With Detailed Immunological Studies

Author Affiliations

From the Department of Medicine, University of Sydney (Drs. Kleerekoper, Basten, and Posen), and the Department of Medicine, University of New South Wales (Dr. Penny), Sydney, Australia.

Arch Intern Med. 1974;134(5):944-947. doi:10.1001/archinte.1974.00320230154028
Abstract

A number of immunological abnormalities have been described in association with idiopathic hypoparathyroidism. These include the presence of circulating antibodies against various tissue antigens,1 abnormal invivo or in-vitro lymphocyte functions,2 and mucocutaneous fungal infections.3,4

In addition, a variety of endocrine and nonendocrine disorders occur in patients with idiopathic hypoparathyroidism,5 including hypoadrenalism,6,7 pernicious anemia,8,9 steatorrhea,10,11 and hypothyroidism.12 To these must be added yet another syndrome—primary amenorrhea or early ovarian failure. In this paper we describe the seventh such recorded case and briefly review the literature. Detailed immunological studies are presented and the association between cellular immune defects and endocrinological abnormalities is discussed.

Patient Summary  A girl was born on Oct 28, 1956, of unrelated parents after an uneventful pregnancy. Her father was 25 years of age and her mother 22 years at the time of her birth. The patient appeared normal in the

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