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January 1975

Biological Properties of Myeloma Proteins

Arch Intern Med. 1975;135(1):32-36. doi:10.1001/archinte.1975.00330010034004

The paraproteins frequently cause major symptoms in patients with plasma cell dyscrasias. This may be due to their quantity in the circulation, to some unusual physicochemical property, or to a biological effect resulting in interaction with other serum proteins. Detection of antibody-combining activity in myeloma proteins has led to important new information on combining-site structure and the kinetics of antigen-antibody-combining activity. Some antibody-combining specificities seem to be present in a higher than expected frequency. As yet, no major therapeutic advances have followed this more precise characterization of the paraprotein, though some interesting possibilities have been explored in animal models.