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February 1975

Coxsackievirus Infection in Mice: Association With Pancreatitis and Subclinical Disease

Author Affiliations

From the Division of Laboratories and Research, New York State Department of Health, Albany, NY. Dr. Smith is now with the Medical School, University of Otago, Dunedin, New Zealand.

Arch Intern Med. 1975;135(2):238-239. doi:10.1001/archinte.1975.00330020042004

White mice of the Nya: NYLAR strain were infected with coxsackie B1 or B4 virus and studied for persistence of virus, antibody conversion, histologic changes, and glucose tolerance during periods up to 13 months. Pancreatitis was observed during the acute phase of infection. Suggestions of subclinical diabetes were found during the first six months after virus inoculation. A normal glucose tolerance at 10 to 13 months suggests that the functional lesion is temporary.

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