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February 1975

Enhanced Tubular Reabsorption of Phosphate: Following Relief of Unilateral Ureteral Obstruction in Man

Author Affiliations

From the Department of Nephrology and the Susan Reba Isenberg Hemodialysis Unit, Rambam Government Hospital, and the Department of Urology, Rotschild Municipal Hospital, and the Aba Khoushy School of Medicine, Haifa, Israel. Dr. Better has been nominated an Established Investigator, Bureau of the Chief Scientist, Ministry of Health, Israel.

Arch Intern Med. 1975;135(2):245-248. doi:10.1001/archinte.1975.00330020049006

Individual kidney functions were studied during water diuresis in eight patients, following the relief of unilateral ureteral obstruction. Fractional excretion of phosphate was diminished in four of the patients, presumably due to enhanced tubular reabsorption of phosphate in the diseased side. Glomerular underperfusion may be the main factor responsible for the hypophosphaturia in the postobstructive kidney. Fractional excretion of sodium and water was increased in the obstructed side in six of the eight patients. In two of the four patients with hypophosphaturia, there was enhanced fractional sodium excretion, suggesting a dissociation of renal handling of sodium and phosphate in some patients with this condition.

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