Two hundred one patients with essential hypertension, who had studies of their renin-aldosterone system performed between April 1967 and December 1972, were surveyed for myocardial infarction or cerebrovascular accident. Of the patients, 42% had low plasma renin activity. Myocardial infarctions or cerebrovascular accidents were documented in 15% of those with low plasma renin activity and in 5% of those with normal plasma renin activity. When adjustments were made for differences in age and blood pressure, a protective effect in low-renin hypertension was not evident. When black patients were considered separately, there was no difference in diastolic blood pressure; however, vascular complications were not less frequent in low-renin hypertensives. The results suggest that low plasma renin activity does not protect against the development of vascular complications in essential hypertension.
Gulati SC, Channick BJ, Adlin EV, Biddle CM, Marks AD. Low-Renin Hypertension: Occurrence in Vascular Complications. Arch Intern Med. 1975;135(2):260–263. doi:10.1001/archinte.1975.00330020064008
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