The population of Evans County, Georgia was surveyed, during a cardiovascular disease study, for the prevalence of corneal arcus. Rates varied with race and sex and increased in prevalence with age in all groups. Arcus was positively correlated with serum cholesterol level. In white males, a significantly higher prevalence rate of coronary heart disease was found in those who had corneal arcus, but arcus was not correlated with subsequent coronary heart disease incidence in any race-sex group.
Barbara Klein, Ronald Klein, Joseph Haseman, Jo Maready, Curtis Hames. Corneal Arcus and Cardiovascular Disease in Evans County, Georgia. Arch Intern Med. 1975;135(4):509–511. doi:10.1001/archinte.1975.00330040021002