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August 1975

Noradrenaline-Secreting Glomus Jugulare Tumor With Cyclic Change of Blood Pressure

Author Affiliations

From the Research Institute of Angiocardiology and Cardiovascular Clinic (Drs. Matsuguchi, Takeshita, Nakamura, and Arakawa) and the Department of Pathology (Dr. Tsuneyoshi), Kyushu University School of Medicine, and the Department of Oto-Rhino-Laryngology, Fukuoka University School of Medicine (Dr. Kato), Fukuoka, Japan. Dr. Arakawa is now at the Department of Internal Medicine, Fukuoka University School of Medicine, Fukuoka, Japan.

Arch Intern Med. 1975;135(8):1110-1113. doi:10.1001/archinte.1975.00330080112018

Since Rosenwasser1 reported the tumor of glomus jugulare in 1945, a number of cases have been reported; however, only a few cases showed evidence of catecholamine secretion.2-5 Glomus jugulare tumor has been considered to originate embryologically in the neural crest and has been classified as a nonchromaffin paraganglioma because of the lack of chromaffinity. Previously only pheochromocytoma, among various neurogenic tumors, had been considered to secrete catecholamine, but since Mason et al6 in 1957 reported a case of adrenaline-secreting neuroblastoma, a close relationship of neurogenic tumors to abnormal catecholamine secretion7 has been recognized.

We report a noradrenaline-secreting tumor of the glomus jugulare with catecholamine granules shown electron microscopically. Continuous recording of blood pressure showed a peculiar cyclic change of the pressure.

METHODS  Catecholamine was measured by a modification of the trihydroxyindole fluorimetric method of von Euler and Floding.8 Levels of urinary total metanephrine (TMN)

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