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November 1975

Long-Term Observations of Glucose Tolerance in Thyrotoxic Patients

Author Affiliations

From the Radioisotope Laboratory, Department of Radiology, and the Metabolism Division, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati.

Arch Intern Med. 1975;135(11):1477-1480. doi:10.1001/archinte.1975.00330110067009

• In an attempt to clarify the clinical importance of glucose intolerance associated with acute thyrotoxicosis, 22 patients had evaluations performed for glucose tolerance while thyrotoxic and at mean follow-up times of 8.8 months and 11.6 years after adequate antithyroid treatment. High incidences of glucose intolerance at long-term follow-up (32%) and of histories suggestive of diabetic diathesis (43%) support the hypothesis that there is an inherited relationship between diabetes mellitus and thyrotoxicosis and suggest that initial testing of all thyrotoxic patients for glucose intolerance is advisable. In addition, all thyrotoxic patients displaying diabetic glucose intolerance after a return to the euthyroid state should be considered to have permanent diabetes mellitus until proved otherwise.

(Arch Intern Med 135:1477-1480,1975)