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December 1975

Transient Red Blood Cell Aplasia in Association With Viral Hepatitis: Occurrence Four Years Apart in Siblings

Author Affiliations

From the Department of Medicine, University of Texas Health Science Center, San Antonio.

Arch Intern Med. 1975;135(12):1585-1589. doi:10.1001/archinte.1975.00330120063009

Various forms of hematopoietic suppression have been reported in viral hepatitis.1 Moderate neutropenia and lymphocytopenia, followed by relative lymphocytosis with reactive lymphocytes, are common in the early stages of the disease,2 and agranulocytosis has been observed.3 Severe, usually fatal, pancytopenia has been described in conjunction with or following hepatitis in at least 30 cases.4 Transient pure erythroid aplasia was observed in a patient with hepatitis attributed to halothane anesthesia.5 In the two patients whose cases are described herein, transient red blood cell (RBC) aplasia with severe anemia was demonstrated during the course of viral hepatitis. Of particular interest is the fact that the patients are siblings whose illnesses occurred four years apart.


Patient1.  —A 26-year-old man (Table) was first admitted to the Bexar County Hospital on April 5, 1972, because of pain in his left ankle and knee. He had been in

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