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February 1976

Nephrosclerosis Postpartum and in Women Taking Oral Contraceptives: A Report of Two Cases

Author Affiliations

From the departments of internal medicine and pathology, Washington University School of Medicine, St Louis.

Arch Intern Med. 1976;136(2):178-185. doi:10.1001/archinte.1976.03630020034009

The condition of a patient with postpartum nephrosclerosis improved during heparin therapy. Review of the literature disclosed 29 other patients with the same histopathologic characteristics, eight of whom also recovered substantial renal function after anticoagulant therapy. Also reported is a patient in whom renal failure occurred while she was taking oral anovulatory agents. Renal biopsy specimen showed the same histopathologic features, which raises the question of similar factors mediating the expression of this disease. We suggest a uniform terminology for this syndrome, either postpartum nephrosclerosis or nephrosclerosis in women taking oral contraceptives.

(Arch Intern Med 136:178-185, 1976)

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