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March 1976

Spectrum of Pleural Involvement in Sarcoidosis

Author Affiliations

From the Pulmonary Disease Division, departments of medicine and pathology, Georgetown University Medical Center, Washington, DC.

Arch Intern Med. 1976;136(3):323-330. doi:10.1001/archinte.1976.03630030055010

Pleural involvement has been considered generally an unusual manifestation of sarcoidosis. When pleural disease is noted in a patient with sarcoidosis, a concomitant disease is usually suspected as the cause of the pleural process. Reports of pleural sarcoidosis have been increasing in the literature recently, but diagnostic criteria for the entity are lacking.

In this paper, five previously unreported cases of sarcoidosis involving the pleura are presented. These cases illustrate the way pleural sarcoidosis may appear, as noncaseating granulomas in the pleura, with or without effusion. While clinical manifestations of pleural involvement caused by sarcoidosis are unusual, histologic involvement may not be as rare as is usually thought.


Patient 1.—  A 32-year-old woman was admitted to Georgetown University Hospital with an eight-month history of fatigue, dry cough, and mild dyspnea on exertion. She denied symptoms of fever, night sweats, or chest pain. On physical examination, the only abnormalities

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