[Skip to Navigation]
March 1976

Intravenously Injected Marihuana Syndrome

Author Affiliations

From the Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor. Dr Farber is now with the University of Virginia, Charlottesville.

Arch Intern Med. 1976;136(3):337-339. doi:10.1001/archinte.1976.03630030069013

We have recently examined two patients who suffered from the adverse effects of intravenously injected marihuana. A review of the English literature identified only four previous case reports1-3 and mention of three others.4 Several recent studies5-8 have described the clinical effects from experimental injection of the purified marihuana components Δ9-tetrahydrocannabinol and 11-OH-Δ9-tetrahydrocannabinol; however, there are no controlled studies dealing with the clinical abnormalities induced by administration of crude marihuana extract. Our two patients shared the same broth and had almost identical clinical and laboratory findings. Their clinical course was similar to that described previously.1-3


Patient 1.—  A 21-year-old man was transferred to the University of Michigan Medical Center after evaluation and treatment for hypotension at a local emergency room. Twenty-two hours prior to admission, he had added the juice squeezed from watered marihuana cuttings to opium and boiled this mixture

Add or change institution