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April 1976

Dialysis in Renal Failure Caused by Amyloidosis of Familial Mediterranean Fever: A Report of Ten Cases

Author Affiliations

From the Department of Nephrology, Soroka Medical Center, and Ben Gurion University of the Negev, and Center for Life Sciences, Beersheba, Israel. Dr Berlyne is an Established Investigator of the Chief Scientist's Office, Israel Minister of Health.

Arch Intern Med. 1976;136(4):449-451. doi:10.1001/archinte.1976.03630040051011

Familial Mediterranean fever (FMF) affects the inhabitants of the Mediterranean littoral and the adjacent areas. In 70% of the cases, FMF results in renal failure, usually in the third or fourth decade, that is caused by renal amyloid deposition with relative sparing of other organs.1,2 In Israel, amyloid attributable to FMF is a major cause of renal failure, and, although at least one case of renal homotransplantation has been recorded in detail,3 there has been no record of the treatment of renal failure by regular hemodialysis in a series of patients with amyloidosis of FMF. In the past five years, we have used regular hemodialysis to treat ten patients who had renal failure caused by amyloidosis of FMF. We found that dialysis produced acceptable results, and that it may prolong comfortable life for years.

SUBJECTS AND METHODS  The ten patients who had FMF were Israeli Jews of Sephardic

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