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June 1976

Hypocalcemia After Therapeutic Use of Magnesium Sulfate

Author Affiliations

From the departments of internal medicine (Dr Eisenbud) and obstetrics and gynecology (Dr LoBue), School of Medicine, University of California, Davis.

Arch Intern Med. 1976;136(6):688-691. doi:10.1001/archinte.1976.03630060040009

It is now recognized that magnesium plays an important role in calcium homeostasis. Although the effects of hypomagnesemia have been frequently reported, little has been written to suggest a clinically important role for hypermagnesemia. A case is reported in which severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration, resulted from the therapeutic use of magnesium sulfate for toxemia of pregnancy. Following recovery, the parathyroid glands were shown to respond normally to a phosphate load. It is suggested that the hypermagnesemia directly suppressed PTH secretion, resulting in symptomatic hypocalcemia.

(Arch Intern Med 136:688-691, 1976)

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