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July 1976

Distressing Side-Effects of Minocycline Hydrochloride

Author Affiliations

From the Department of Medicine, University of Vermont College of Medicine, Burlington.

Arch Intern Med. 1976;136(7):761-762. doi:10.1001/archinte.1976.03630070009005

Minocycline hydrochloride is a tetracycline derivative that has been advocated as the drug of choice in the treatment of meningococcal carriers. Recently, we studied a group of 30 patients who experienced a large number of sideeffects after receiving minocycline for treatment of meningococcal meningitis. Twenty-seven of 30 (90%) suffered from dizziness, vertigo, ataxia, weakness, nausea, and vomiting. These symptoms appeared within the first 72 hours of taking minocycline, and disappeared within 48 hours of stopping the medication.

(Arch Intern Med 136:761-762, 1976)

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