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July 1976

Malaria Complicating Neoplastic Disease

Author Affiliations

From the Infectious Disease Sevice, Department of Medicine, Memorial Sloan-Kettering Cancer Center, and Cornell University Medical College, New York.

Arch Intern Med. 1976;136(7):807-810. doi:10.1001/archinte.1976.03630070051016

Two patients with neoplastic disease had transfusion-induced malaria. In a patient with acute myelogenous leukemia infected with Plasmodium vivax, neither his underlying disease nor intensive cytotoxic chemotherapy appeared to ameliorate or worsen the clinical course of his infection. In a splenectomized patient with metastatic carcinoma of the colon, P malariae infection was associated with a fulminant course simulating cerebral malaria. Despite delay in diagnosis, both patients responded dramatically to antimalarial chemotherapy and both developed appreciable antibody responses.

(Arch Intern Med 136:807-810, 1976)