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July 1976

Respiratory Paralysis During Treatment of Hypertension With Trimethaphan Camsylate

Author Affiliations

From the Department of Medicine, Upstate Medical Center, State University of New York, Syracuse, NY.

Arch Intern Med. 1976;136(7):816-818. doi:10.1001/archinte.1976.03630070060018

Four cases are reported in which respiratory arrest occurred coincident with the intravenous administration of large doses of trimethaphan camsylate (Arfonad) to control hypertension. The mechanism of the respiratory depression is unknown, but it may have been related to a direct effect of trimethaphan on the respiratory center or to a curare-like effect of the drug. Close monitoring of ventilatory capacity should be maintained in all patients treated with trimethaphan.

(Arch Intern Med 136:816-818, 1976)