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July 1976

Partial Deletion of Long Arm of Chromosome 17: A Specific Abnormality in Acute Promyelocytic Leukemia?

Author Affiliations

From the departments of medicine (Drs Golomb, Rowley, Baron, and Locker) and pathology (Dr Vardiman), University of Chicago Hospitals and Clinics, the Franklin McLean Memorial Research Institute, Chicago, and West Suburban Hospital, Oak Park, Ill (Dr Krasnow).

Arch Intern Med. 1976;136(7):825-828. doi:10.1001/archinte.1976.03630070063019

Two patients with acute promyelocytic leukemia had an identical chromosomal abnormality detected by fluorescence banding. In each case, the clinical course was rapidly fatal, and was characterized by a lack of response to chemotherapy with cytarabine and thioguanine, and was complicated by disseminated intravascular coagulation. Bone marrow cells from each patient contained 46 chromosomes; in each instance, however, one chromosome 17 had a deletion of almost one half of the proximal portion of the long arm [del(17)(q11q21 or 22)].

(Arch Intern Med 136:825-828, 1976)