Two patients with acute promyelocytic leukemia had an identical chromosomal abnormality detected by fluorescence banding. In each case, the clinical course was rapidly fatal, and was characterized by a lack of response to chemotherapy with cytarabine and thioguanine, and was complicated by disseminated intravascular coagulation. Bone marrow cells from each patient contained 46 chromosomes; in each instance, however, one chromosome 17 had a deletion of almost one half of the proximal portion of the long arm [del(17)(q11q21 or 22)].
(Arch Intern Med 136:825-828, 1976)
Golomb HM, Rowley J, Vardiman J, Baron J, Locker G, Krasnow S. Partial Deletion of Long Arm of Chromosome 17: A Specific Abnormality in Acute Promyelocytic Leukemia? Arch Intern Med. 1976;136(7):825–828. doi:10.1001/archinte.1976.03630070063019
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