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July 1976

Goodpasture Syndrome: Recovery After Severe Renal Insufficiency

Author Affiliations

From the Department of Medicine, University and Veterans Administration Hospitals, Iowa City (Drs Cohen and Freeman); and the Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, Calif (Dr Wilson).

Arch Intern Med. 1976;136(7):835-837. doi:10.1001/archinte.1976.03630070073021

Goodpasture syndrome, the association of pulmonary hemorrhage with antiglomerular basement membrane (anti-GBM)-mediated proliferative glomerulonephritis, usually results in irreversible renal failure. Patients who survive without chronic hemodialysis or renal homotransplantation have rarely had severe renal involvement. We describe a patient whose condition improved after an episode of acute renal failure.

PATIENT SUMMARY  A 22-year-old white woman was admitted to the University Hospitals on March 10, 1972, with a three-hour history of cough, blood-tinged sputum, and shortness of breath. She had been in excellent health, except for a two-day episode of rhinitis and headache one week before admission. She denied chills, fever, sputum production, or previous pulmonary or cardiovascular complaints. She had been treated for a urinary tract infection with antibiotics at 11 years of age. Four years before admission, she was given birth control pills because of heavy menstrual flow. Her hematocrit value had been 41% in November 1969 during a routine

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