The incidence and parameters associated with diarrhea related to clindamycin usage were studied in a population of both inpatients and outpatients. Diarrhea occurred in 66 (6.6%) of the 1,000 patients. In three of them, substantial morbidity was associated with the diarrhea. Of the multiple parameters that were evaluated, a significant association with diarrhea was found only for age (patients over the age of 20 years) (P <.01) and sex (females) (P <.005). Interestingly, dose, duration, and route of administration showed no significant relationship to diarrhea (P >.05).
(Arch Intern Med 136:876-879, 1976)
Swartzberg JE, Maresca RM, Remington JS. Gastrointestinal Side Effects Associated With Clindamycin: 1,000 Consecutive Patients. Arch Intern Med. 1976;136(8):876–879. doi:10.1001/archinte.1976.03630080018007
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