The incidence of and mortality associated with colon cancer has not decreased during the past 25 years despite several innovations in therapy. Earlier detection and prevention by polypectomy through the sigmoidoscope and colonoscope have been suggested as one alternative offering improvement. The polyp-cancer sequence is controversial, but recent evidence indicates that polyps with a papillary component have a substantial potential for becoming malignant. Fortyfour polyps were resected from 26 patients. Nineteen polyps from 14 patients had papillary features or "in-situ" carcinoma. Thus, colonoscopic polypectomy may play an important role not only in early detection but also in the prevention of colon cancer.
(Arch Intern Med 136:890-892, 1976)
Skibba RM, Gourley WK, Klotz AP. Early Detection and Prevention of Colon Cancer: The Role of Colonoscopy. Arch Intern Med. 1976;136(8):890–892. doi:10.1001/archinte.1976.03630080032011
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