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September 1976

Heinz Body Hemolytic Anemia

Author Affiliations

Beverly Hills, Calif

Arch Intern Med. 1976;136(9):1067. doi:10.1001/archinte.1976.03630090089024

To the Editor.—  I am surprised that Dr Greenberg,1 in republishing his earlier findings,2 failed to mention several earlier publications describing the typical occurrence of "bitten-out" red cells in drug-induced, oxidative, Heinz body hemolytic anemia. This morphologic change has been used by hematologists to screen for this disorder.3He also fails to mention a detailed study on the mechanism of phenazopyridine-induced Heinz body hemolytic anemia in non-glucose-6-phosphate dehydrogenase (G6PD)-deficient subjects,4 which describes the bitten-out red cells in this condition (p 757) as well as in vitro studies on the oxidative hemolytic potential of this compound.