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September 1976

Estrogen and Bone Loss

Arch Intern Med. 1976;136(9):1068. doi:10.1001/archinte.1976.03630090090027

To the Editor.—  The article by Meema et al1 quotes our longitudinal study2 on the prevention of postmenopausal osteoporosis and adds some interesting data observed during a period of a few years. However, I feel that I must correct a misconception that the authors have and add some comments.It is stated that our study "used radiologic measurements in bones of the hand for quantitative estimation of bone loss." In fact, bone mineral measurements were made by this technique only at the start of our prospective trial and only then to allow comparison with a previously described normal population within western Scotland.3 Bone loss and its prevention by estrogen was measured by photon absorption with the use of a modification4 of the original technique by Cameron and Sorensen.5 Although we did measure the second metacarpal bone, our group as well as other groups have shown