[Skip to Navigation]
October 1976

Idiopathic Pulmonary Hemosiderosis: Ultrastructural Studies and Response to Azathioprine

Author Affiliations

From the departments of medicine (Drs Yeager, Weinberg, and Katz), pediatrics (Dr Bellanti), and pathology (Drs Powell and Bauer), Georgetown University School of Medicine, Washington, DC.

Arch Intern Med. 1976;136(10):1145-1149. doi:10.1001/archinte.1976.03630100057015

Two boys are presented who fulfilled criteria for a diagnosis of idiopathic pulmonary hemosiderosis. A lung biopsy specimen from the first patient showed alveolar-capillary basement membrane abnormalities, together with abnormalities of capillary endothelial cells and hemosiderin-laden macrophages. A lung biopsy specimen from the second patient showed mainly capillary endothelial abnormalities and interstitial fibrosis. Both patients had a noticeable improvement in symptoms and relative stabilization of their roentgenographic and pulmonary function abnormalities following azathioprine therapy.

(Arch Intern Med 136:1145-1149, 1976)