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October 1976

Histiocytosis X and Compulsive Water Drinking: Report of a Case

Arch Intern Med. 1976;136(10):1150-1153. doi:10.1001/archinte.1976.03630100062016

Diabetes insipidus is a known complication of histiocytosis X.1 We report a patient with compulsive water drinking and histiocytosis X. To the best of our knowledge, this association has not been noted previously. In addition, this patient was of interest because the results of a Carter and Robbins modification2 of the Hickey-Hare test3 were initially misleading and suggested the presence of diabetes insipidus. Adverse consequences resulted from treating the patient with vasopressin injection (Pitressin).

PATIENT SUMMARY  A 39-year-old woman was referred to the Minneapolis Veterans Hospital for evaluation of polyuria. She had a history of pulmonary infiltrates for 14 years (Fig 1), diagnosed by lung biopsy two years before admission as histiocytosis X (eosinophilic granuloma) (Fig 2). Seven months before admission, she noted an onset of polydipsia and polyuria (5 to 14 liters/day).One month before admission to the Minneapolis VA Hospital, she was admitted to another