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October 1976

Resin Hemoperfusion For Acute Drug Intoxication

Author Affiliations

Springfield, Ill.

Arch Intern Med. 1976;136(10):1197. doi:10.1001/archinte.1976.03630100105031

To the Editor.—  In his latest contribution to the study of the treatment of severe drug intoxication, Dr Rosenbaum and associates1 described ten hemoperfusions performed on eight patients. The procedure used a 650-gm column of Amberlite XAD-4 resin and was shown to be more effective than any known method of removing barbiturates and glutethimide from the blood of patients with drug overdoses.Previous publication by Rosenbaum and associates dating back to 19702-5 have established that this macroreticular resin is effective in the treatment of drug overdose with methaqualone, ethchlorvynol, and all intermediate and long-acting barbiturates or combinations thereof. No clinical data have been published regarding the effectiveness of this resin in the treatment of patients with meprobamate intoxication.We recently were asked to see a 35-year-old woman who had ingested 20 gm of meprobamate 12 hours prior to her transfer to Memorial Medical Center. During those first 12 hours

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