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November 1976

Vitamin D Metabolism in Man: Effect of Corticosteroids

Author Affiliations

From the Section of Endocrinology and Metabolism, Department of Medicine, University of Kansas Medical Center, Kansas City, Kan.

Arch Intern Med. 1976;136(11):1241-1248. doi:10.1001/archinte.1976.03630110017008

This study evaluated the effects of acute intravenous calcium supplementation on vitamin D metabolism in nine patients maintained on long-term prednisone therapy for chronic obstructive lung disease. Vitamin D turnover studies, employing 1,2-3H,414C vitamin D3 and coincident measurement of serum 25-hydroxycholecalciferol (25-OHCC) concentrations demonstrated that intravenous calcium administration decreased the mean 25-OHCC concentration (P <.05) and half-time (P <.05) in the prednisone-treated patients when compared with the mean 25-OHCC concentration and half-time found in these patients prior to calcium infusion. However, there was no significant difference in the amounts of 24,25-dihydroxycholecalciferol (24,25-(OH)2CC) or 1,25-dihydroxycholecalciferol (1,25-(OH)2CC) appearing after calcium infusion. The results of the study showed that the intravenous administration of calcium to corticosteroidtreated patients accelerated the disappearance of 25-OHCC from the plasma of these patients without parallel increases in the production of 1,25-(OH)2CC or 24,25-(OH)2CC.

(Arch Intern Med 136:1241-1248, 1976)

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