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November 1976

Herpesvirus hominis Hepatitis and Disseminated Intravascular Coagulation: Occurrence in an Adult With Pemphigus Vulgaris

Author Affiliations

From the Departments of Dermatology (Drs Keane and Malkinson), Medicine (Dr Levin), and Pathology (Dr Bryant), Rush-Presbyterian-St Luke's Medical Center, Chicago.

Arch Intern Med. 1976;136(11):1312-1317. doi:10.1001/archinte.1976.03630110072019

Herpesvirus hominis (HVH) hepatitis, a rarely recognized manifestation of HVH infection in adults, occurred in a 36-year-old woman who had received prednisone therapy for pemphigus vulgaris continuously for seven years. After an acute terminal illness that was characterized by fulminant hepatic failure and disseminated intravascular coagulation (DIC), postmortem examination disclosed massive hepatic necrosis. Herpesvirus hominis (type 1) was isolated from the liver. The association of disseminated HVH infection with impaired immunologic defenses, as well as the occurrence of DIC in association with acute hepatic failure, are discussed. Greater awareness of the clinical manifestations of HVH hepatitis should lead to early diagnosis, although successful modes of therapy await development.

(Arch Intern Med 136:1312-1317, 1976)

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