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December 1976

Gallium Citrate Ga 67 Scanning: Clinical Usefulness in Lymphoma Patients

Author Affiliations

From the Departments of Internal Medicine (Drs Seabold, Votaw, Keyes, and Balachandran) and Radiology (Drs Foley and Keyes), University of Michigan Medical School. Ann Arbor. Dr Seabold is now with the University of Texas System Cancer Center, Houston.

Arch Intern Med. 1976;136(12):1370-1374. doi:10.1001/archinte.1976.03630120022010

Gallium citrate Ga 67 (67Ga) scans were performed in 50 consecutive lymphoma patients who underwent routine staging. The overall accuracy of67Ga scans was greater than 80% for all nodal sites except the spleen (63%). Sensitivity was greater than 88% in the neck and mediastinum, 67% in the abdomen-pelvis, and 33% for the spleen. Specificity was greater than 85% for all nodal sites except for the mediastinum (67%). The accuracy of pedal lymphangiograms was 75%, sensitivity 87%, and specificity 68%. Gallium 67 scans complemented the lymphogram in the abdomen-pelvis but, due to limited sensitivity and high number of equivocal studies (16%), did not replace it. Infraclavicular, pectoral, and mediastinal lesions were detected by67Ga scans when missed by other means. In 20% to 25% of patients,47Ga scans provided information not afforded by other diagnostic studies and are therefore considered an important staging procedure for lymphoma patients.

(Arch Intern Med 136:1370-1374, 1976)