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December 1976

Grounds for Optimism in Treating Acute Granulocytic Leukemia (Adult Acute Leukemia): A Look at the Data

Author Affiliations

From the Department of Developmental Therapeutics, University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston.

Arch Intern Med. 1976;136(12):1375-1376. doi:10.1001/archinte.1976.03630120027011

In the July 1974 issue of the Archives, an editorial under this title presented an extraordinarily negative view of the results of treatment of acute granulocytic leukemia. The editorial suggested that many publications and workers in the field were excessively optimistic in their assessment of treatment results. The author's pessimism was confirmed by his own reanalysis of published data. This position was coupled with the implication that patients participating in clinical research programs at major treatment centers were receiving less than optimal therapy. This editorial stimulated a number of dissenters to prepare letters to the editor and editorial commentaries in other publications. However, editorial comment tends to reflect the views of the author more than the actual results of significant clinical research. It has been my feeling that it would be extremely timely to attempt to review the current state of the management of this disease by asking individuals who

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