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January 1977

Successful Treatment of Acute Leukemia During Pregnancy: Combination Therapy in the Third Trimester

Author Affiliations

From the Section of Hematology and Oncology, Department of Internal Medicine (Dr Durie), and the Department of Obstetrics and Gynecology (Dr Giles), University of Arizona College of Medicine, Tucson.

Arch Intern Med. 1977;137(1):90-91. doi:10.1001/archinte.1977.03630130062015

Aggressive treatment with cytarabine, vincristine sulfate, and prednisone for acute myelogenous leukemia, administered from the 31st week of pregnancy, resulted in both sustained complete remission of the leukemia and delivery of a normal infant with a normal birthweight and a normal male karyotype. It is concluded that chemotherapy with cytarabine combinations can be administered in the third, and probably the second, trimester of pregnancy without risk of serious damage to the developing fetus.

(Arch Intern Med 137:90-91, 1977)