A 45-year-old man underwent a jejunoileal shunt procedure for obesity. Twenty months later he developed severe oxalosis and chronic renal failure, which required maintenance hemodialysis. The sequential observation of two biopsy specimens and the necropsy (over a span of 39 months) suggests that oxalate deposition caused tubular obstruction and destruction with subsequent atrophy of nephrons. This indicates that patients undergoing intestinal bypass are at risk for developing irreversible renal failure due to enteric hyperoxaluria.
(Arch Intern Med 137:239-243, 1977)
Gelbart DR, Brewer LL, Fajardo LF, Weinstein AB. Oxalosis and Chronic Renal Failure After Intestinal Bypass. Arch Intern Med. 1977;137(2):239–243. doi:10.1001/archinte.1977.03630140085017
Customize your JAMA Network experience by selecting one or more topics from the list below.