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March 1977

Focal Nodular Hyperplasia of the Liver Associated With High-Dosage Estrogens

Author Affiliations

From the Division of Gastroenterology and the Department of Diagnostic Radiology, University of Texas Medical School at Houston.

Arch Intern Med. 1977;137(3):357-359. doi:10.1001/archinte.1977.03630150057016

A patient developed benign nodular hyperplasia of the liver after long-term, high-dose estrogen therapy. A 10.5-cm benign liver nodule appeared after three years of high-dose estrogen therapy and was resected. Fourteen months later, while still receiving estrogen, a 4.5-cm nodule and multiple small nodules were seen on angiography. Four months after estrogen was discontinued, the large liver nodule disappeared and the smaller ones decreased.

(Arch Intern Med 113:357-359, 1977)

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