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March 1977

Colchicine Toxicity: A Multisystem Disease

Author Affiliations

From the Division of Hematology, Departments of Medicine and Pathology, Pacific Medical Center, San Francisco.

Arch Intern Med. 1977;137(3):394-396. doi:10.1001/archinte.1977.03630150088024

A 23-year-old black man survived a life-threatening multisystem disturbance resulting from a large single dose of colchicine administered intraurethrally for condyloma acuminata. Gastroenteritis and probable pancreatitis rapidly evolved into severe respiratory failure, marked neuromuscular problems, alopecia, and complete bone marrow aplasia. Within two months he had completely recovered. This patient demonstrates that colchicine should be used with extreme caution, if at all, for the therapy of condyloma acuminata.

(Arch Intern Med 137:394-396, 1977)

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