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April 1977

RBC Transfusions in Paroxysmal Nocturnal Hemoglobinuria

Author Affiliations

From the Departments of Medicine, University of Kentucky, Lexington (Dr Gockerman), and Walter Reed Army Medical Center, Washington, DC (Dr Brouillard).

Arch Intern Med. 1977;137(4):536-538. doi:10.1001/archinte.1977.03630160092019

Frozen-thawed, deglycerolized RBCs can be substituted for saline-washed RBCs for transfusion of patients with paroxysmal nocturnal hemoglobinuria (PNH). The effect of transfusion is to decrease bone marrow production of RBCs, which results in a decreased percentage of complement-sensitive erythrocytes. In the presence of small numbers of complement-sensitive erythrocytes, major vascular surgery can be performed without hemolytic problems. This study suggests that the percentage of complement-sensitive RBCs, as well as the complement sensitivity of these cells, influence the severity of hemolysis in persons with PNH.

(Arch Intern Med 137:536-538, 1977)

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