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May 1977

Studies With an Artificial Endocrine Pancreas

Author Affiliations

From the Hospital for Sick Children, the Toronto General Hospital, the Mount Sinai Hospital, and the University of Toronto.

Arch Intern Med. 1977;137(5):639-649. doi:10.1001/archinte.1977.03630170055015

Short-term studies with an artificial endocrine pancreas have provided insights into the pathophysiology of diabetes and demonstrated the ability of such a system to restore and maintain glucose homeostasis in human subjects given either their usual diet, a 50 gm oral glucose tolerance test, or a moderate level of physical exercise. Animals were used to demonstrate that a peripheral route of insulin delivery by the artificial pancreas is equivalent to the portal route.

(Arch Intern Med 137:639-649, 1977)

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