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June 1977

Attempted Treatment of Inoperable Pheochromocytoma With Streptozocin

Author Affiliations

From the Veterans Administration Hospital and University of Maryland School of Medicine, Baltimore.

Arch Intern Med. 1977;137(6):762-765. doi:10.1001/archinte.1977.03630180042013

Currently the only treatment available for inoperable pheochromocytoma is symptomatic and palliative with α- and β-adrenergic blockade. Pheochromocytoma is a tumor of chromaffin tissue derived from the neural crest and closely related to other APUD (amine precursor uptake and decarboxylation) cell tumors, including those of the pancreatic islets. Streptozocin has been used with varying success in some of these tumors and therefore merited a trial in pheochromocytoma. We used streptozocin to treat two patients with inoperable pheochromocytoma; the drug failed to have any effect, either on catecholamine excretion or tumor growth.

(Arch Intern Med 137:762-765, 1977)