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July 1977

Hypertension Induced by Irradiation to the Kidney

Arch Intern Med. 1977;137(7):840-841. doi:10.1001/archinte.1977.03630190008004

The classic descriptions of Gold-blatt and of Page on the experimental production of unilateral renal hypertension stimulated vast and continued interest in the role of the kidney in hypertension. In recent years, most attention has been focused on atherosclerotic or fibrous lesions of the renal arteries or their major branches as causes of reversible renal hypertension. It is well to remember that a number of other renal disorders may be responsible for potentially curable hypertension. As far back as 1956, Homer Smith's1 review of the world literature concerning the cure of hypertension by unilateral nephrectomy showed that fully one fourth of 575 patients remained normotensive after nephrectomy. The renal parenchymal diseases that may give rise to unilateral or predominantly one-sided disease with hypertension include chronic pyelonephritis, tuberculosis, hydronephrosis, neoplasm, trauma, renal infarction, and radiation nephritis.

Also in 1956, Levitt and Oram2 reported a case of malignant hypertension that

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