A patient with short-bowel syndrome developed severe hypomagnesemia (0.2 mEq/liter) associated with symptomatic hypocalcemia (6.1 mg/100 ml). Parathyroid hormone (PTH) levels were normal but inappropriately low. During therapy with magnesium sulfate, an initial hypocalcemia was followed by a calcemic response without a change in PTH levels. This indicates improved bone responsiveness to circulating low levels of endogenous PTH with magnesium replenishment, which appears to be related to the restoration of magnesium-dependent cellular mechanisms. The additional observation of a slow and delayed increase in PTH, despite normal calcium levels, indicates improvement of hormone synthesis.
(Arch Intern Med 137:953-955, 1977)
Wiegmann T, Kaye M. Hypomagnesemic Hypocalcemia: Early Serum Calcium and Late Parathyroid Hormone Increase With Magnesium Therapy. Arch Intern Med. 1977;137(7):953–955. doi:10.1001/archinte.1977.03630190097025
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.