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July 1977

Hypomagnesemic Hypocalcemia: Early Serum Calcium and Late Parathyroid Hormone Increase With Magnesium Therapy

Author Affiliations

From the Division of Nephrology, Montreal General Hospital.

Arch Intern Med. 1977;137(7):953-955. doi:10.1001/archinte.1977.03630190097025

A patient with short-bowel syndrome developed severe hypomagnesemia (0.2 mEq/liter) associated with symptomatic hypocalcemia (6.1 mg/100 ml). Parathyroid hormone (PTH) levels were normal but inappropriately low. During therapy with magnesium sulfate, an initial hypocalcemia was followed by a calcemic response without a change in PTH levels. This indicates improved bone responsiveness to circulating low levels of endogenous PTH with magnesium replenishment, which appears to be related to the restoration of magnesium-dependent cellular mechanisms. The additional observation of a slow and delayed increase in PTH, despite normal calcium levels, indicates improvement of hormone synthesis.

(Arch Intern Med 137:953-955, 1977)

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