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September 1977

Adult Hemolytic-Uremic Syndrome: Familial Variant

Author Affiliations

From the Department of Medicine, Washington University School of Medicine, St Louis (Dr Karlsberg); and the Department of Medicine, University of Colorado Medical Center, Denver, and the Southern Colorado Clinic, Pueblo (Drs Lacher and Bartecchi).

Arch Intern Med. 1977;137(9):1155-1157. doi:10.1001/archinte.1977.03630210037011

We describe here a family with hemolytic-uremic syndrome culminating in renal failure and severe hypertension in the involved male adults. Members of this family developed a microangiopathic hemolytic anemia, progressive renal failure, the onset of elevation of blood pressure, and an untimely death in young adulthood. One affected family member has survived the initial crisis. The family history presents further evidence for an autosomal dominant pattern of inheritance of hemolytic-uremic syndrome with presentation in adulthood.

(Arch Intern Med 137:1155-1157, 1977)