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September 1977

Prothrombin Complex Concentrate: Use in a Hemophiliac With a Factor VIII Inhibitor

Author Affiliations

From the Department of Medicine, University of Southern California School of Medicine and Los Angeles County-University of Southern California Medical Center, Los Angeles.

Arch Intern Med. 1977;137(9):1211-1213. doi:10.1001/archinte.1977.03630210083025

A hemophiliac with a factor VIII inhibitor was bleeding massively from an extensive surgical wound. After ten days of unsuccessful management by conservative measures, he was given a single infusion of prothrombin complex concentrate (Konyne). Bleeding stopped immediately and the wound healed without further recurrence of bleeding. Although the activated partial thromboplastin time shortened following the infusion, the exact physiologic mechanism whereby these concentrates bypass the need for factor VIII clotting activity is unknown.

(Arch Intern Med 137:1211-1213, 1977)

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