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Article
November 1977

Teichoic Acid Antibody Test: Its Use in Patients With Coagulase-Positive Staphylococcal Bacteremia

Author Affiliations

From the Department of Bacteriology and Immunology (Drs Larinkari and M. Valtonen), University of Helsinki, the Central Public Health Laboratory (Dr Sarvas), and the Second Department of Medicine (Dr V. Valtonen), University Central Hospital, Helsinki.

Arch Intern Med. 1977;137(11):1522-1525. doi:10.1001/archinte.1977.03630230018008
Abstract

We have studied the occurrence and specificity of teichoic acid antibodies (TAAs), measured by double diffusion in agar, in 114 patients with bacteremia of whom 47 had coagulase-positive staphylococcal bacteremia. A total of 30% of the 47 patients with coagulase-positive staphylococcal bacteremia had a TAA titer of 1:8 or more, and an additional 30% had a titer of 1:2 or 1:4. High TAA titers were most often connected with coagulasepositive staphylococcal endocarditis, osteomyelitis, and deep wound infections. None of the six coagulase-negative patients with staphylococcal bacteremia nor any of the 92 controls had titers exceeding 1:1. A total of 10% of the other patients with bacteremia showed positive results on the TAA test at low titer levels. Compared to the antistaphylolysin value, the TAA test was about equally specific but more sensitive.

(Arch Intern Med 137:1522-1525, 1977)

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