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January 1978

Primary Amyloidosis With Familial Vitreous Opacities: An Unusual Case and Family

Author Affiliations

From the Second Department of Internal Medicine (Drs Okayama, Ogata, and Omae), the Department of Neurology, Neurological Institute (Dr Goto), the Second Department of Pathology (Dr Yoshida), and the Department of Ophthalmology (Dr Inomata), Faculty of Medicine Kyushu University, Fukuoka, Japan.

Arch Intern Med. 1978;138(1):105-111. doi:10.1001/archinte.1978.03630250069021

Peripheral neuropathy was not found even six to ten years after the onset of visual symptoms in a family with primary amyloidosis, except in the propositus at the terminal stage. The propositus had mainly ocular and CNS involvement. An ocular manifestation, the vitreous opacity, was the only involvement in the family members, in spite of the long clinical course. This family may have a different type of familial primary amyloidosis from that previously reported.

(Arch Intern Med 138:105-111, 1978)

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