A prospective randomized trial between two drug regimens in 38 patients with advanced pancreatic carcinoma was performed. The two-drug regimen consisted of carmustine and fluorouracil. The survival rate and response to these two drugs was compared to a three-drug regimen consisting of these same two drugs plus spironolactone. Objective partial responses were rare in both groups, being 3/18 in the two-drug group and 2/20 in the three-drug group. Life table analysis in previously untreated patients from time of treatment shows longer survival for the three-drug group, but this difference was not statistically significant.
(Arch Intern Med 138:115-117, 1978)
Stephens RL, Hoogstraten B, Haas C, Clark G. Pancreatic Cancer Treated With Carmustine, Fluorouracil, and Spironolactone: A Randomized Study. Arch Intern Med. 1978;138(1):115–117. doi:10.1001/archinte.1978.03630250077022
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