[Skip to Content]
[Skip to Content Landing]
February 1978

Long-Term Blood Pressure Changes in Renal Homotransplantation

Author Affiliations

From the Dialysis and Transplantation Department (Drs Jacquot, Idatte, Bedrossian, and Bariety), Clinique Médicale, Hôpital Broussais, Université Paris VI; and the Hemodynamic Laboratory, Research Unit on Hypertension (Drs Weiss and Safar), Hôpital Broussais, Universite Paris VI.

Arch Intern Med. 1978;138(2):233-236. doi:10.1001/archinte.1978.03630260041014

Long-term blood pressure changes were studied in 50 patients who had undergone renal homotransplantation. Excluded were those subjects with arterial stenosis of the transplanted kidney, acute or rapidly progressive rejection, or recurrent glomerulonephritis, as well as those retaining their own diseased kidney(s). The blood pressure after the end of the first year was stable and, therefore, was utilized as the reference blood pressure for this study. One year after transplantation, hypertension was observed in 20% of the patients. Mean blood pressure was positively correlated with age (P <.01), body weight (P <.001), and serum creatinine level (P <.001), and negatively correlated with maintenance dose of prednisone (P <.01). A higher incidence of hypertension was observed in cadaver kidney transplantation than in living related-donor transplantation. The study minimizes the role of glucocorticoids and emphasizes the role of renal factors in the mechanism of the long-term blood pressure changes.

(Arch Intern Med 138:233-236, 1978)