Acute uric acid nephropathy is a reversible type of renal failure that results from the deposition of uric acid crystals in the collecting tubules. The present study has compared a number of laboratory tests in 5 patients with a clinical diagnosis of this disorder and 27 patients with acute renal failure of other causes. Neither the serum creatinine, BUN, serum urate concentrations, nor the ratio of serum urate:BUN differentiated between these two groups of patients. However, the ratio of uric acid to creatinine concentration on a random urine specimen did differentiate between these two patient populations. All patients with uric acid nephropathy had a ratio greater than 1.0, while all patients with other types of acute renal failure had ratios of less than 1.0.
(Arch Intern Med 138:612-615, 1978)
Kelton J, Kelley WN, Holmes EW. A Rapid Method for the Diagnosis of Acute Uric Acid Nephropathy. Arch Intern Med. 1978;138(4):612–615. doi:10.1001/archinte.1978.03630280074023
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: