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April 1978

A Rapid Method for the Diagnosis of Acute Uric Acid Nephropathy

Author Affiliations

From the Departments of Medicine, Division of Rheumatic and Genetic Diseases, Duke University Medical Center, Durham, NC (Drs Kelley and Holmes), and University Hospital, University of Western Ontario, London, Ontario, Canada (Dr Kelton). Dr Kelley is now with the Department of Medicine, University of Michigan Medical School, Ann Arbor. Dr Holmes is an investigator with the Howard Hughes Medical Institute.

Arch Intern Med. 1978;138(4):612-615. doi:10.1001/archinte.1978.03630280074023

Acute uric acid nephropathy is a reversible type of renal failure that results from the deposition of uric acid crystals in the collecting tubules. The present study has compared a number of laboratory tests in 5 patients with a clinical diagnosis of this disorder and 27 patients with acute renal failure of other causes. Neither the serum creatinine, BUN, serum urate concentrations, nor the ratio of serum urate:BUN differentiated between these two groups of patients. However, the ratio of uric acid to creatinine concentration on a random urine specimen did differentiate between these two patient populations. All patients with uric acid nephropathy had a ratio greater than 1.0, while all patients with other types of acute renal failure had ratios of less than 1.0.

(Arch Intern Med 138:612-615, 1978)