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June 1978

Disseminated Strongyloides stercoralis Infection: Association With Ectopic ACTH Syndrome and Depressed Cell-Mediated Immunity

Author Affiliations

From the Department of Internal Medicine, University of Virginia Medical Center, Charlottesville. Dr Horwitz is the recipient of a clinical scholar award from the arthritis Foundation, Atlanta.

Arch Intern Med. 1978;138(6):1005-1006. doi:10.1001/archinte.1978.03630310081027

A patient with disseminated Strongyloides stercoralis was evaluated to elucidate host factors that may have led to the development of this infection. The patient was found to have oat cell carcinoma with hypercortisolism produced by tumor adrenocorticotropic hormone. His serum contained a potent inhibitor of lymphocyte blastogenesis. This patient's high level of endogenous cortisol may have impaired lymphocyte function and thereby facilitated infection with S stercoralis.

(Arch Intern Med 138:1005-1006, 1978)