Salicylazosulfapyridine has been used for a number of years as therapy for ulcerative colitis. Reported toxicities are usually minor. This case report represents an acute allergic reaction to the drug, characterized by fever, rash, eosinophilia, nephritis, and hepatitis. Resolution occurred with discontinuation of salicylazosulfapyridine. Although similar reactions have been reported with the antimicrobial sulfonamides, none has been fully described with salicylazosulfapyridine, a combination of a sulfonamide and salicylate.
(Arch Intern Med 138:1138-1139, 1978)
Chester AC, Diamond LH, Schreiner GE. Hypersensitivity to SalicylazosulfapyridineRenal and Hepatic Toxic Reactions. Arch Intern Med. 1978;138(7):1138–1139. doi:10.1001/archinte.1978.03630320074025
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