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September 1978

The Pathophysiology and Treatment of Gastroesophageal Reflux DiseaseNew Concepts

Arch Intern Med. 1978;138(9):1398-1401. doi:10.1001/archinte.1978.03630340068021

Gastroesophageal reflux disease refers to a clinical syndrome produced by the passage of gastric contents into the esophagus. The syndrome is usually manifested by the symptoms of heartburn, and may lead to the sequelae of esophagitis, stricture, or peptic ulcer of the esophagus. The frequency of the syndrome is unknown since most persons report symptoms of heartburn at some time. The sequelae or complications of gastroesophageal reflux are less common, but yet present a major problem for the practicing physician. Recent developments in the pathophysiology of gastroesophageal reflux now provide a better understanding for the diagnosis and treatment of this disorder.

The purpose of this review is to discuss (1) recent developments in the pathophysiological mechanism of gastroesophageal reflux; (2) a rational clinical approach to the documentation of gastroesophageal reflux and its complications; and (3) the recent advances in the medical and surgical therapy of this disorder.


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